Actinomadura madurae, maduropeptin

Van Lanen, S.G., Oh, T.J., Liu, W. et al. (2007) Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis. Journal of the American Chemical Society, 129, 13082. [Pg.258]

The previously known kedarcidin chromophore (7) is revised to CCC (7559), and the mechanism of action of this enediyne has been studied (1560). The new maduropeptin chromophore 1601 was isolated from Actinomadura madurae, which is associated with a protein of 14 amino acids (1561-1563). The non-protein associated enediyne N1999A2 (1602) was characterized from Streptomyces sp. AJ 9493 (1564), and confirmed by synthesis (1565,1566). [Pg.233]

Maduropeptin (MDP) 17, isolated in 1991 from the broth filtrate of Actinomadura madurae, consists of a 1 1 complex of an acidic water-soluble carrier apoprotein (32 kDa) and a labile enediyne chromophore, and showed potent antibacterial and antitumor activities [7]. The MDP apoprotein represented at that time a new protein class showing no sequence homology to the related chromoproteins neocarzistatin, auromomycin, actinoxanthin, C-1027, or kedarcidin, which were all in the 11.5-kDa... [Pg.75]

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