Actinic keratoses glycolic acid

Glycolic acid or Jessner s solution with 5 % 5-fluorouracil was found to be useful for the treat-meut of widespread actinic keratoses (AKs) in a group of 31 patients [319]. At least 80 % clearing of tVKs was noted, with an overall improvanent in photodamaged skin in this group [319]. 

Light chemical peels include 20-35% TCA, 70% glycolic acid, and Jessner s solution (resorcinol, salicylic acid, lactic acid, and ethanol) and penetrate the entire epidermis. These peels are more effective than the very light peels for the treatment of actinic keratoses, solar lentigenes, and epidermal growths such as thin seborrheic keratoses. Skin texture may also be improved. Erythema and scaling will occur postoperatively however healing time is faster if... 

Glycolic acid peels are used as adjunctive treatments in conditions such as acne, postinflammatory hyperpigmentation usually resulting from acne, shallow acne scars, papulopustular rosacea, melasma, seborrheic and actinic keratoses, keratosis pilaris, and some warts resistant to conventional treatments. 

There are many treatment options for actinic keratoses, as listed in Table 4.1. Nevertheless, glycolic acid peels can be added to that list. The use of glycolic acid peels in combination with 5-fluorouracil is recommended to ensure treatment of the actinic keratoses. It is felt that alpha-hydroxy acids increase skin permeability and thereby may enhance penetration and increase the efficacy... 

---