ACTH and protein kinase

C-kinase in the adrenal cortex presence and steroidogenic effects 

Several steroidogenic hormones activate phospholipase C, causing breakdown of PIP2 to two intracellular messengers, DG and IP3 (Fig. 8). Calcium is mobilized from intracellular stores by IP3 and DG activates the calcium- and phospholipid-dependent protein kinase C (C-kinase) [3]. 

Protein kinase C is present in the adrenocortical cell, and phorbol esters, which are potent activators of protein kinase C, stimulate adrenocortical steroidogenesis [62] and cell growth [63]. 

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