Acridone alkaloids occurrence

C]Tryptophan gave inactive alkaloids but tritiated 2,4-dihydroxy-quinoline (34) and its N-methyl derivative were incorporated into (47) (0.009 % and 0.020% respectively) an early route had suggested the derivation of what was essentially (34) from tryptophan. Radioisotope dilution showed the presence of both these quinoline precursors together with iV-acetyl- and N-methyl-anthranilic acid in A. baueri. A satisfactory incorporation of N-methylanthranilic acid into (47) was found in Evodia xanthoxyloides, and this, together with its natural occurrence, indicates that early methylation may be important in the biosynthesis of acridone alkaloids. 

Occurrence.- Table 2 lists known acridone alkaloids... 

Table 24.11 Occurrence of acridone alkaloids in O 8 N 1 A ll = 1 R Rutaceae 1 1 1 4 species...

Table 24.12 Occurrence of acridone alkaloids in non-nitaceous species...

Table 24.17 Occurrence of dimeric acridone alkaloids in Rutaceae species...

Addendum. A comprehensive review on the occurrence of alkaloids in the Rutaceae family has appeared. The broad spectrum of alkaloid types, including quinolines, furoquinolines, and acridones, may be appreciated from the list of species given in this review. 

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