Aconite neuromuscular blocking effect

Fig. (12). Main constituents of aconite and the neuromuscular blocking effect of aconite extract and its constituents in mouse phrenic nerve-diaphragm muscle preparation. The inhibition percentage of nerve-evoked twitch response is plotted against the log concentration (g/mL) of each constituent. The values represent means S.E.M. (n = 3-10).

Atractylodes lancea rhizome and aconite root are paeoniflorin, glycyrrhizin, P-eudesmol, and aconitine, respectively. Each compound plays a complementary role, having different mechanisms of action. Their mechanisms in combined (blend) effects of paired or triplet combinations of these compounds have been investigated, and the rationality of the traditional combined medicines has been elucidated. The neuromuscular blocking actions have been compared by using skeletal muscle in vitro and in situ, and in normal and diseased states. 

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