Acnistus Withanolides

Veleiro, A., Burton, G. and Gros, E. (1985) Biosynthesis of withanolides in Acnistus breviorus. Phytochemistry, 24, 2263-6. [Pg.362]

Nittala SS, Vande VV, Lrolow F, Lavie D (1981) Chlorinated withanolides fiom Withania somnifera and Acnistus breviflorus. Phytochemistry 20 2547—2552... [Pg.3491]

Cardero CP, Morantes SJ, Paez A, Rincon, Aristiazabal FA (2009) Cytotoxicity of withanolides isolated from Acnistus arborescens. Fitoterapia 80 364—368... [Pg.3492]

Minguzzi S, Barata LES, Shin YG, Jtmas PF, Chai HB, Park EJ, Pezzuto JM, Cordell GA (2002) Cytotoxic withanolides frtun Acnistus arborescens. Phytochemistry 59 635-641... [Pg.3492]

Functionalized Withanolides. Withacnistin (18-hydroxy-27-deoxy-withaferin A) was discovered along with withaferin A (Fig. 7.27) as a constituent of Acnistus... [Pg.473]

Veleiro AS, Oberti JC, Burton G (2005) Chemistry and bioactivity of withanolides from South American Solanaceae. In Atta-ur-Rahmtm (ed) Studies in natural products chemistry, vol 32 (part L). Elsevier, Amsterdam, NL, pp 1019-1052 Veras ML, Bezerra MZB, Lemos TLG, Uchoa DEA, Braz-Frlho R, Chai HB, Cordell GA, Pessoa ODL, (2004a) Cytotoxic withaphysalins from the leaves of Acnistus arborescens. J Nat Prod 67 710-713... [Pg.520]

Chemical studies on the leaf constituents of Acnistus arborescens [200], Withania somnifera [201-204], W. coagulens [205], and Jaborosa integrifoUa [206-208] have resulted in the discoveiy of the withanolides and jaboro-solides. One member of this group of steroidal lactones, withaferin A (L), has been found to be active against the experimental neoplasms W 256 and S 180. However, the therapeutic index of this compound is too small to warrant further pharmacological study [209]. [Pg.30]

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