Acidophilic cell lesion

Hepatic lesions in the case of yellow fever are more likely to correspond to those of hepatosis, (s. p. 404) There is also evidence of distinct acidophilic hepatocellular necrosis as well as microvesicular fatty degeneration of the hepatocytes. Hyaline, eosinophilic inclusions in the cytoplasm of degenerated hepatic cells (so-called Councilman bodies) are characteristic and were first identified by w.T. Councilman in 1890 in yellow fever (s. p. 396). Acidophilic inclusion bodies in the hepatocellular nuclei which are arranged concentrically around the nucleolus (so-called Torres corpuscles) correspond to the yellow fever virus (C.M. Torres, 1928). The liver does not present any significant signs of inflammation. The reticular fibre structure is maintained, so that the liver architecture is usually completely restored-provided the outcome of the disease is favourable, (s. fig. 23.4)... 

Similar lesions with constitution of protmding areas are observed through contact with concentrated acids such as 98 % sulfuric acid. A 4 min exposure is sufficient to get significantly altered epidermis morphology (Fig. 3.22). Strong acan-tholysis makes bubbles at the base of the stratum comeum, observed by areas. In these areas, kera-tinocytes show a net nuclear pyknosis and cytoplasmic alterations, especially in the upper layers. In spinous and basal layers, cells have a significantly pyknotic nucleus with a net acidophilic cytoplasm. 

A delay in the appearance of lesions until the 15th minute in comparison with non-washed explants. As for the exposed and non-washed sample, epidermal cells have relatively pyk-notic nuclei with slightly acidophilic cytoplasms whereas this aspect is more important in the two sublayers of dermis. 

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