Acidity reserve

The most frequent protein in the plasma, at around 45 g is albumin. Due to its high concentration, it plays a crucial role in maintaining the blood s colloid osmotic pressure and represents an important amino acid reserve for the body. Albumin has binding sites for apolar substances and therefore functions as a transport protein for long-chain fatty acids, bilirubin, drugs, and some steroid hormones and vitamins. In addition, serum albumin binds Ca "" and Mg "" ions. It is the only important plasma protein that is not glycosylated. 

Acidity Reserve Acidity Reserve Acidity Reserve... 

There is considerable evidence that smoking depletes ascorbic acid reserves (4,142,156,255-257,269), as shown by diminished whole blood, serum, and leukocyte ascorbate levels in smokers relative to nonsmoker controls. It would be presumptuous to say that this difference reflects an increased utilization acting in a protective capacity. Nevertheless, in the present state of our knowledge, it would seem a wise precaution for the compulsive heavy smoker to increase deliberately his ascorbate intake. 

Mercapturic acid production seems to have first call on the sulphur amino acid reserves and serious deficiency states can be induced in rats by hepatotoxic hydrocarbons. Diets high in cysteine and methionine will protect against the liver damage. Some mercapturic acid production may also result from reaction of protein thiol groups with the hydrocarbons, hydrolysis of the protein to the S-substituted cysteine and its N-acylation. However, the vast majority is formed via the glutathione adducts if the hydrocarbon dose is not so great as to deplete the glutathione reserves of the liver. 

Folic deficiency was thought to be rare in humans, but more and more cases of deficiency were reported as the methods for diagnosis improved. It is now sometimes assumed to be one of the most common vitamin deficiencies. In humans, megaloblastic anemia develops after five months of administration of a folic acid-deficient diet, suggesting that it takes that long to deplete the body of its folic acid reserves or sources. The exact human requirements for folic acid are unknown, but it is estimated that 50-250 pg of folic acid is required daily in adults and 5-20 pg in infants. These figures are based on the hematological response observed in patients with folic acid deficiency. 

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