Acidic hydrolysis, /?-amido alcohols from

In the first case, reaction with amines leads to amides amido acids formed when amines react with cyclic anhydrides can be recyclized to cyclic imides (p. 344). When mixed acyclic or asymmetrical cyclic anhydrides react, a mixture of products can be formed, although the stronger acid usually gives an ester (or amide) (56). Reaction of alcohols with anhydrides very often takes place even in the cold certain anhydrides, however, are resistent to heat and can be crystallized from ethanol (57) they can be cleaved by heating with sodium ethoxide in ethanol or benzene. If the acids formed by hydrolysis are solid and suitable for identification, this procedure can be considered as the simplest for identification purposes. When anhydrides of liquid acids are to be identified, the reaction with aromatic amines is generally employed mixed anhydrides are best identified by chromatography of acids formed on alkaline hydrolysis. 

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