Acid-labile anchors

Breipohl G, Knolle J, Stuber W. Synthesis and application of acid labile anchor groups for the synthesis of peptide amides by Fmoc-solid-phase peptide synthesis. Int J Peptide Protein Res 1989 34 262-267. 

Seiber P. A new acid-labile anchor groups for the solid phase synthesis of C-terminal peptide amides by the Fmoc method. Tetrahedron Lett 1987 28 2107-2110. 

M. Megler, R Tanner, J Gosteli, P Grogg. Peptide synthesis by a combination of solid phase and solution methods. 1. A new very acid-labile anchor group for the solid phase synthesis of protected fragments on 2-methoxy-4-alkoxy-benzyl resins. Tetrahedron Lett 29, 4005, 1988. 

The second subgroup, which contains the largest number of acid-labile anchors, can be characterized by their ability to form stable cations. Typical members of this group include functional groups linked with benzyl-, benzhydryl- and trityl-anchor (Fig. 5.4). 

Very acid-labile anchor, even HOBt can partially cleave the product from the solid support (this problem is circumvented by adding DIEA). 

Siebl987 Sieber, P, A New Acid-Labile Anchor Group for the Solid-Phase Synthesis of C-Terminal Peptide Amides by the Fmoc Method, Tetrahedron Lett., 28 (1987) 2107-2110. 

Albericio F, Barany G (1987) An acid-labile anchoring linkage for solid-phase synthesis of C-terminal peptide amides imder nuld conditions. Int J Pept Protein Res 30 206-216... 

Sieber P (1987) A new acid-labile anchor group for the solid-phase synthesis of C-terminal peptide amides by the Fmoc method. Tetrahedron Lett 28 2107-2110 Mende F, Seitz O (2011) 9-Fluorenylmethoxycarbonyl-based solid-phase synthesis of peptide a-thioesters. Angew Chem Int Ed 50 1232-1240 Giiillier F, Grain D, Bradley M (2000) Linkers and cleavage strategies in solid-phase organic synthesis and combinatorial chemistry. Chem Rev 100 2091-2158... 

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