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Acid chloride reaction with lithium diorganocopper

Note that the diorganocopper reaction occurs only with acid chlorides. Carboxylic acids, esters, acid anhydrides, and amides do not react with lithium diorganocopper reagents. [Pg.805]

Acid chlorides react readily with lithium diorganocopper (Gilman) reagents (Section 15.2) to give ketones, as illustrated by the conversion of pentanoyl chloride to 2-hexanone. The reaction is carried out at -78°C in either diethyl ether or tetrahy-drofuran. Following hydrolysis in aqueous acid, the ketone is isolated in good yield. [Pg.769]

How could you prepare the following ketones by reaction of an acid chloride with a lithium diorganocopper reagent ... [Pg.806]

Coupling reaction of a lithium diorganocopper with an acid chloride to yield a ketone (Sec. 21.4)... [Pg.869]

See other pages where Acid chloride reaction with lithium diorganocopper is mentioned: [Pg.864]    [Pg.805]    [Pg.805]    [Pg.419]    [Pg.662]    [Pg.834]   


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Lithium chloride, reaction

Reaction with lithium

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