Ceftriaxone Aciclovir

Retrospective data from children surest that ceftriaxone might have increased the renal toxicity of intravenous aciclovir. Ce-falexin does not appear to alter the absorption of valaciclovir to a clinically relevant extent. 

A retrospective analysis of 17 children who had received intravenous aciclovir and ceftriaxone for suspected meningo-encephalitis revealed that 12 developed a significant increase in serum creatinine, and three of these developed acute renal failure. This rate of renal toxicity is higher than that seen with aciclovir alone, and was attributed to the concurrent use of ceftriaxone. The dose of aciclovir correlated with nephrotoxicity. The authors concluded that caution is required with the combination, and that renal function should be monitored if both drugs are needed. ... 

A 23-year-old man, with no significant past medical history except obesity, was treated with intravenous aciclovir and ceftriaxone for suspected encephalitis or meningitis. Within 48 h of commencing aciclovir there was marked deterioration in his renal function. This returned to normal when the aciclovir was stopped. No other cause for the deterioration was found. This patient weighed 111.5 kg and received intravenous aciclovir 10 mg/kg eight hourly. 

Nephrolithiasis, urinary crystals or debris Aciclovir, amoxicillin, atazanavir [17],ciprofloxacin, ephedrine/guaifenesin, floctafenine [18], indinavir [19], magnesium trisilicate, methotrexate, primidone, sulfasalazine [20], sulfonamides, triamterene [21,22] ceftriaxone [23,24] felbamate [25] ketamine [26] Djenkol beans [27] Microscopy, infrared spectroscopy. X-ray diffraction, mass spectroscopy... 

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See also in sourсe #XX -- [ ]

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