Achilles Tendinopathy

Four cases of tendinopathy have been reported in three men and one woman taking statins (60). The diagnoses were extensor tenosynovitis in the hands, tenosynovitis of the tibialis anterior tendon, and Achilles tendinopathy. Two patients were taking simvastatin and two atorvastatin. The tendinopathy developed 1-2 months after the start of treatment. The outcome was consistently favorable within 1-2 months after drug withdrawal. 

Donck JB, Segaert MF, Vanrenterghem YF. Fluoroquinolones and Achilles tendinopathy in renal transplant recipients. Transplantation 1994 58(6) 736-7. 

Gladue H, Kaplan MJ. Achilles tendinopathy after treatment with ophthalmic moxifloxacin. J Rheumatol 2013 40(l) 104r-5. 

Astrom, M. 1998. Partial rupture in chronic achilles tendinopathy A retrospective analysis of 342 cases. Acta Orthopaedica 69 404-407. 

Peck RJ, Metreweli C (1988) Early myositis ossificans a new echographic sign. Clin Radiol 39 586-588 Peers KHE, Brys PPM, Lysens RJJ (2003) Correlation between power Doppler ultrasonography and clinical severity in Achilles tendinopathy. Int Orthop 27 180-183 Peetrons P (2002) Ultrasound of muscles. Eur Radiol 1235-43... 

Based on histopathologic examination findings, Achilles tendinopathy may be further subdivided into tendinosis and paratendinitis (Maffulli et al. 1998). These conditions should be considered separate entities although they often coexist and present with similar findings. In the acute phases of Achilles tendinopathy the tendon is diffusely swollen and edematous and symptoms include pain and stiffness with limitation in daily activities, whereas in... 

Achilles tendon rupture without any sudden pain occurred in a 45-year-old female runner who developed bilateral tendinopathy of the Achilles tendon after repeated treatment with ciprofloxacin histological analysis showed cystic changes with focal necrosis (50). 

Tendinopathy has been reported with levofloxacin. Four cases of Achilles tendinitis have been reported in patients taking levofloxacin (29). Two were on chronic dialysis, one was a kidney transplant recipient, and one had chronic vasculitis. In all four cases, tendinitis had an acute onset with bilateral involvement and was incapacitating. In three cases the onset was early during levofloxacin treatment and in one case it began 10 days after the end of treatment. AH the patients recovered completely after 3-8 weeks. 

Schweitzer ME, Karasick D (2000) MR imaging of disorders of the Achilles tendon. AJR Am J Roentgenol 175 613-625 Sharma P, MaffuUi N (2005) Tendon injury and tendinopathy healing and repair. J Bone Joint Surg Am 87 187-202 Silvestri E, Biggi E, Molfetta L et al (2003) Power Doppler analysis of tendon vascularization. Int J Tissue React 25 149-158... 

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