Acetyltryptophanamide

Figure 1 (a) Absorption and fluorescence spectra of fluorescent amino acids blocked with peptide bonds N-acetyltryptophanamide (black),... 

A report by Lulka and Chambers [27] describes the properties of surface-imprinted silicas using A-acetyltryptophanamide (NATA) or fluorescein (Fig. 20.9) as templates. Silica gel was mixed with bis(2-hydroxyethyl)-aminopropyltriethoxysi-lane (as functional monomer), tetraethoxysilane and the template and the slurry... 

Lulka and co-workers have imprinted two fluorescent compounds, fluorescein (Fig. 2, 6) and A-acetyltryptophanamide (NATA) (Fig. 2,7) with organic silanes bis (2-hydroxyethyl) -aminopropryltriethoxysilane (HAPTES) and tetraethoxysilane (TES) [23]. The binding constants were determined with steady-state fluorescence spectroscopy. It was found that high affinity binding sites with Kj s in the range of sub - to low micromolar were achieved. 

NATA, N-L-acetyltryptophanamide BSND, benzenesulfonamide BSFN, benzenesulfonate Sta, statine BZD, benzamidine CFM, coformycin MTX, methotrexate TMP, trimethoprim PT, pterin NPT, N5-deazapterin THP, tetrahydropyrrole Bz, benzene ADA, adenosine deaminase HCAIl, human carbonic anhydrase II TS, thymidyiate synifaase DHFR, dihydrofolate reductase MBP, mannose bindnig protein HEI, hydroxyethylene inhibitor HPR, (6R)-6-hydroxy-l,6 dihydropurine riboside (R),R configuration (S),S configuration NA, not available or not applicable. 

Miyamoto and Kollman used AMBER 4.0 and X-ray data to calculate the absolute free energy of association of N-L-acetyltryptophanamide... 

Table 12.1 Values of the lifetime of NATA (N-acetyltryptophanamide) in dioxane/water solutions with variable percentages of water [6],...

The recently discovered enzyme tryptophane side chain a, 3-oxidase dehydrogenates acetyltryptophanamide and other peptides containing tryptophane. Apart from the fact that no hydrogen peroxide is formed... 

Noda, Y., K. Takai, T. Tokuyama, S. Narumiya, H. Ushiro, and O. Hayaishi Enzymatic Oxidation of Acetyltryptophanamide- and Tryptophan-Containing Peptides. Formation of Dehydrotryptophan. J. Biol. Chem. 252, 4413 (1977). 

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