6-0-acetylmorphine glucuronid

Svensson JO, Andersson M, Gustavsson E, Beck O (2007) Electrospray LC-MS method with solid-phase extraction for accurate determination of morphine-, codeine-, and ethylmorphine-glucuronides and 6-acetylmorphine in urine. J Anal Toxicol 31(2) 81-86... 

Heroin is rapidly metabolized in humans 22 and other species 451 452 to 6-acetylmorphine and morphine, the active metabolites/100 Compounds lacking a free 3-0 H function bind poorly to opioid receptor preparations, and heroin was no exception. Morphine and 6-acetylmorphine bound well to receptor preparations, and the binding of the latter accounted for all the apparent binding of heroin. In addition to 6-acetylmorphine and morphine, the 3-glucuronide of morphine (261) occurred as a major metabolite of heroin... 

Elimination of heroin (diacetylmorphine) is 80% renal. Metabolic inactivation mainly gives morphine-3-glucuronide together with a few percent of the metabolites 6-monoacetylmorphine, non-conjugated morphine and normorphine. Unchanged diacetylmorphine can be detected only in trace amounts if at all. The hydrolysis of heroin via 3-acetylmorphine takes place to a small extent only [44],... 

MO, morphine-3-glucuronide (MSG), morphme-6-glucuronide (M6G), COD, dihydrocodeine, noscapine, PV, and 6-acetylmorphine... 

WW First study to target a spectrum of illicit drugs and metabolites (in WWTP infiuents and effluents) those not identified in prior studies norbenzoylecgonine, norcocaine, cocaethylene, 6-acetylmorphine, morphine-3-D-glucuronide, amphetamine, MDA, MDEA, EDDP, 1 l-nor-9-carboxy-9-THC Castiglioni et al. (2006)... 

Tables 18.1,18.2, and 18.3 hst concentration measurements madeatdiEferenttimes during regular classes, final exams, and the summer when few students were present, respectively. A -Tetrahydrocannabinol (THC) is the major psychoactive compound in marijuana. THC is rapidly oxidized to 11-hydroxy THC and then to ll-nor-9-carboxy-A -THC, which is the main metabolite excreted. The main metabolic route of cocaine involves the hydrolysis of ester linkages to produce benzoylecgonine (BE). 6-Acetylmorphine is the main specific metabolite of heroin (3,6-diacetylmorphine). Codeine is O3 -methylmorphine. Morphine-3 p-glucuronide is a metabolite formed in vivo by the attachment of a sngar to the O3 oxygen, which facilitates elimination of morphine from the body. All three of these morphine-based derivatives are narcotics. 3,4-Methylenedioxymethamphetamine (MDMA) and 3,4-metltylenedioxy-amphetamine (MDA) are amphetamine derivatives that are commonly referred to as ecstasy.

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