Acetylglucosamine-l-phosphate

Hoff, J. E. 1963. Determination of N-acetylglucosamine-l-phosphate and IV-acetylgluco-samine in milk. J. Dairy Sci. 46, 573-574. 

Kostrewa D, D Arcy A, Takacs B et al (2001) Crystal structures of Streptococcus pneumoniae N-acetylglucosamine-l-phosphate uridyltransferase, GlmU, in apo form at 2.33 A resolution and in complex with UDP-N-acetylglucosamine and Mg(2+) at 1.96 A resolution. J Mol Biol 305 279-289... 

The most likely steps where benzoylureas may be active are the last two steps the assembly of Uridine diphosphate N-acetyl-glucosamine from UTP and N-acetylglucosamine-l-phosphate and the polymerization of N-acetylglucosamine from UDP-N-acetylglucosamine under the mediation of chitin synthetase. Since studies [Gijswijt, et al., 1979] have indicated that benzoylurea intoxication is accompanied by the buildup of UDP-N-acetylglucosamine, the latter... 

JV-acetylglucosamine-e-phosphate — JV-acetylglucosamine-l-phosphate IV-acetylglucosamine-l-pliosphate + UTP — UDPAG + PP... 

Sulzenbacher, G., Gal, L., Peneff, C., Fassy, F., and Bourne, Y. (2001). Crystal structure of Streptococcus pneumoniae N-acetylglucosamine-1-phosphate uridyl transferase bound to acetyl-coenzyme A reveals a novel active site architecture. J. Biol. Chem. 276, 11844-11851. 

Figure 17-5. Synthesis of the mannose 6-phosphate recognition marker. R represents the high-mannose oligosaccharide of newly synthesized lysosomal enzymes. Reaction 1 is catalyzed by UDP-A,-acetylglucosamine lysosomal enzyme Ar-acetylglucosaminyl-1 -phosphotransferase. Reaction 2 is catalyzed by iV-acetylglucosamine-l-phosphodiester-iV-ace tylgluco saminidase.

Weidanz, J.A. Campbell, R Moore, D. DeLucas, L.J. Roden, L. Thompson, J.N. Vezza, A.C. N-acetylglucosamine kinase and N-acetylglucosamine 6-phosphate deacetylase in normal human erythrocytes and Plasmodium falciparum. Br. J. Haematol., 95, 645-653 (1996)... 

Yadav, V., Panilaitis, B., Shi, H., Numuta, K., Lee, K., Kaplan, D.L., 2011. N-acetylglucosamine 6-phosphate deacetylase (nagA) is required for N-acetyl glucosamine assimilation in Gluconacetobacter xylinus. PloS One 6 (6), el8099. 

Fig. 8.1 Biosynthesis of peptidoglycan. The large circles represent A -acetylglucosamine orN-acetylmuramic acid to the latter is linked initially a pentapeptide chain comprising L-alanine, D-glutamic acid and meso-diaminopiraelic acid (small circles) terminating in two D-alanine residues (small, darker circles). The lipid molecule is undecaprenyl phosphate. In the initial (cytoplasm) stage where inhibition by the antibiotic D-cycloserine is shown, two molecules of Dalanine (small circles) are converted by an isomerase to the D-forms (small, darker circles), alter which a ligase joins the two D-alanines together to produce a D-alanyl-D-alanine dipeptide.

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