Acetylcholine muscarinic agonist analogs

An alternative approach uses the distance geometry paradigm, in which all the constraints are combined to form the distance matrix from which energetically feasible conformations of the set of molecules are sought mathematically. Sheridan et al. (439) demonstrated this approach on acetylcholine analogs that are muscarinic agonists. Both of these approaches ask the same question and suffer from the same limitations, and differ only in computational technique. Each suffers from the local minima problem, in that each uses a... 

Structural and conformational analogies and interatomic distance similarities between pilocarpine and muscarinic agonists such as acetylcholine, acetyl /3-methylcholme, muscarine, and muscarone have been invoked... 

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