Acetylcholine inhibition 3-quinuclidinyl benzilate

Fusetani, N. Asai, N. Matsunaga, S. Honda, K. Yasumuro, K. (1994) Cyclostell tamines A-F, pyridine alkaloids which inhibit binding ofmethyl quinuclidinyl benzilate to muscarinic acetylcholine receptors, from the marine sponge, Stelletta maxima. Tetrahedron Lett., 35, 3967-70. 

List of Abbreviations DMXB-A, 3-(2,4-dimethoxybenzylidene)-anabaseine mAChR, muscarinic acetylcholine receptor nAChR, nicotinic acetylcholine receptor NDMC, N-desmethylclozapine PPI, prepulse inhibition QNB, quinuclidinyl benzilate... 

As shown in Fig. 2 and Table 1, xanomeline displayed higher affinity than CDD-0102 in binding to M, and M, muscarinic acetylcholine receptors, as measured by the inhibition of pH](/ )-quinuclidinyl benzilate (QNB) binding. Both compounds exhibited higher affinity for Mj receptors than for M, receptors, a common finding with muscarinic agonists. This may reflect inherent differences between receptors coupled to the G and G families of G proteins. 

Cyclostellettamines A-F, Pyridine Alkaloids which Inhibit Binding of Methyl Quinuclidinyl Benzilate (QNB) to Muscarinic Acetylcholine Receptors, from the Marine Sponge Stelletta maxima. Fusetani, N. Asai, N. Honda, K. and Yasumuro, K. Tetrahedron Lett, 1994, 35, 3967. 

---