Acetyl p-anisidine

Acetyl-o-anisidine Acetyl -m-anisidine Acetyl-p-anisidine Acetyl-o-phenetidine Acetyl-mphenetidine Acetyl-p-phenetidine (or phenacetin) Acetyl-a-naphthylamine Acetyl-p-naphthylamine... 

For example, in a preparation of A-methyl-p-anisidine, iV-acetyl-p-anisidine was first metalated with sodamide in boiling toluene and then, in the same operation, methylated with dimethyl sulfate at 100° and finally hydrolysed by alkali.724... 

The reaction of terephthalic acid (as suspended solid particles) with ethylene oxide dissolved in n-butanol to give bis(2-hydroxyethyl) terephthalate (which is the monomer in the manufacture of polyethylene terephthalate) occurs in regime 1 (Bhatia et al., 1976). Nitration of solid aromatic compounds such as naphthalene and acetylated p-anisidine proceeds in regime 3. 

Acetylated p-anisidine (46) /)-nitrophenol sulphate (major) and glucoside (total 54)... 

N-Acetyl-p-anisidine K2CO3 copper bronze PhN02... 

Preparationbyliiedel-CiaflsdiloroacetylalxxiofN-acetyl-p-anisidine followed by hydrolysis with concentrated hydrochloric acid in ethanol [4555,4613,4614]. m.p. 135° [4555,4614], 128° [4613]. 

According to Trautman (16), PNA was converted almost exclusively to p-nitrophenol in the mouse with 24 hours, nearly all of which was excreted in the urine as glucuronide, sulfate, glucoside, and unextractable products the mouse tissue retained only about 1% of the original dose. By comparison, the sea urchin metabolized PNA slowly p-nitrophenol and its conjugates accounted for only about 6% of the metabolites and most of the remainder (90%) was p-anisidine (p-methoxyaniline) and its N-acetyl derivative. 

A study by Hayashi et al. demonstrates that less reactive electron-rich aromatic aldehydes efficiently undergo Mannich reactions under high pressure induced by water freezing [8], For instance, in the Mannich reaction of p-anisaldehyde, 3,4-dimethoxybenzaldehyde or N-acetyl-(4-formyl)aniline, with acetone and p-anisidine, good yields (61-99%) and excellent enantioselectivities (92-97%) have been obtained under water-freezing high-pressure conditions while there is no reaction at room temperature at 0.1 MPa (Scheme 9.6). 

Even aromatic amines can be acylated in an aqueous medium. For example, p-anisidine was dissolved in dilute acetic acid for acetylation.723,cf 724 Further, amines can often be brought to reaction as mineral salts in aqueous solution,725 the mineral acid liberated being buffered by sodium acetate.726... 

The A -[ C]acetyl group is a less common subunit in compounds selected for long-term in vivo investigations in life science, even though enzymatic hydrolysis is slower than for ester groups . [l- C]Acetylpractolol (29). for example, has been found in animal and human in vivo studies to be deacylated by less than It was prepared in one step upon treatment of the etherified p-anisidine 2 with [l- C]acetyl chloride in about 75% radiochemical yield by maintaining the reaction at pH 4-6 . ... 

Me ether 4 6-dinitro-m-anisidine. YeUow needles. M,p. 208°. N-Acetyl 4 6-dinitro-m-acetanisidide. M.p. 146°... 

Me ether 6-iodo-o-anisidine. C HgONI. MW, 249. Cryst. from EtOH.Aq. M.p. 49°. N-Acetyl 6-iodo-o-acetanisidide. -M.p. 176°. 

Periodate oxidation of j/V-acetyl-A-)3-D-glycopyranosyl-p-bromoaniline or its /7-anisidine analogue followed by condensation with nitromethane yielded the corresponding iV-acetyl-(3-deoxy-3-nitro-A-j8-D-glucopyranosyl) aniline as the major product in both cases. 

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