Acetyl mandelyl chloride

Anschutz gives the boiling point of acetyl mandelyl chloride as i29°/io mm. The vacuum used should be as low as possible, to avoid the formation of tar during the distillation. 

Acetyl mandelic acid was described by Naquet and Lougui-nine,1 but their product has been shown to be contaminated with the ethyl ester of acetyl mandelic acid. Dupont2 obtained the compound by the oxidation of diacetyl 1, 4-diphenylbutine-2-diol-i, 4. Anschutz and Bocker3 prepared acetyl mandelic acid, and from it the acid chloride, by the use of phosphorus pentachloride, but with poor yields. Von Braun and Muller 4 state that acetyl mandelyl chloride can be made from acetylated mandelic acid and thionyl chloride, the resulting product being a viscous yellow oil. 

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