Acetyl hypofluonte

Into a suspension of 8 g of sodium acetate m 400 mL of a solution of 1 part acetic acid and 10 parts fluorotnchloromethane is passed at -75 C a stream of fluonne diluted to 10% with nitrogen The reacuon is stirred with a Vibromixer A solution of 4-methylacetanilide (20 mmol) in a mixture of dichloromethane and fluorotnchloromethane cooled to -75 °C i s added to 20 mmol of acetyl hypofluonte as determined by titration with potassium iodide After 5 min the mixture is poured into water, and the orgamc layer is washed with sodium bicarbonate soluaon and dried over anhydrous magnesium sulfate After concentrauon and column chromatography over silica gel and elution with chloroform, 2-fluoro-4-methylacetanilide IS obtained m 85% yield... 

A, [ F]fluorine diluted with an unreactive gas B, [ F]acetyl hypofluorite. For companson with F]F2, the radiocherracal yields obtained with acetyl hypofluonte need to be divided by 2... 

Fluoroxytrifluoromethane (trifluoromethyl hypofluorite) and acetyl hypofluonte are the most commonly used neutral hypofluorites, cesium fluoroxysulfate is an inorganic anionic fluoroxy derivative... 

The heterocyclic system bimane produces a difluonnated product on fluonnation with acetyl hypofluonte [34 (equation 11)... 

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