2- Acetoxymethyl-3-methylquinoxaline 1,4-dioxide

Acetoxymethyl-3-methylquinoxaline gave 2-acetoxymethyl-3-methylquinoxa-line 1,4-dioxide (244) (excess m-ClC6H4C03H, CHCI3, 20°C reflux, 16 h ... 

Acetoxymethyl-7-acetyl-2-quinoxalinecarboxamide 1-oxide 2-Acetoxymethyl-3-benzoylquinoxaline 4-oxide 2-Acetoxymethyl-5-methoxy-3-methylquinoxaline 2-Acetoxymethyl-5-methoxy-3-methylquinoxaline 1,4-dioxide 2-Acetoxymethyl-3-methylquinoxaline... 

Treatment of 2,3-dimethylquinoxaline dioxides and monoxides with acetic anhydride yield 2,3-bis(acetoxymethyl)quinoxalines and 2-acetoxymethylquinoxalines, respectively.112,208 Under alkaline conditions these derivatives are hydrolyzed to the corresponding hydroxy-methylquinoxalines. Thus, 2-methyl-3-phenylquinoxaline-1,4-dioxide... 

Quinoxaline 1,4-dioxide (Quindoxin) has higher antibacterial activity under in vivo than under in vitro conditions. It has been shown that its in vitro activity is enhanced 10 to 100-fold under anaerobic conditions. Derivatives of 3-methylquinoxaline 2-carboxaldehyde 1,4-dioxide such as the N-methylnitrone 86 also have higher in vivo activity than would be expected from in vitro tests. The high in vivo activity of 2,3-dimethyl-quinoxaline 1,4-dioxide is due to the formation of active metabolites, the mono- and dihydroxymethyl derivatives 87 and 88. However the hydroxymethyl derivative of 86 did not show the expected enhanced activity. Compound 88 is referred to in the literature as Dioxidine, and 2,3-bis(acetoxymethyl)quinoxaline 1,4-dioxide is known as Quinoxidine. The trade name for the 2-carboxaldehyde 1,4-dioxide derivative (89) is Car-badox. Of the numerous quinoxaline 1,4-dioxide derivatives patented in... 

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