Acetorphan, enkephalinase inhibitor

Roge J, Baumer P, Berard H, Schwartz JC, Lecomte JM The enkephalinase inhibitor, acetorphan, in acute diarrhoea. A doubleblind, controlled clinical trial versus loperamide. Scand J Gastroenterol 1993 28 352-354. 

The enkephalinase inhibitors, candoxatril (UK 79 300), the indanyl ester (pro-drug) of the (+)-isomer of candoxatrilat (UK 69 578) (see Figure 6.5) [130,131] and sinorphan ((5)-acetorphan) (see Figure 6.12) [132] are undergoing evaluation in humans for hypertension and congestive heart failure. The cardiovascular effects of SCH 34826 (see Figure 6.12) [133] have also been assessed. 

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