Acetonitrile compounds

An isomeric mixture of the pyridotriazine derivatives 129 and 130 was obtained in the reaction of 2-aminopyridine with perfluoro-5-azanon-4-ene 128 in the presence of triethylamine in acetonitrile. Compounds 129 and 130 were isolated in 40% and 13% yield, respectively, beside some side products (Equation 16) <2000JFC(103)105>. 

Dialkylation of 376 with 375 can also be done simply by using 2equiv of triethylamine in acetonitrile. Compound... 

Columns. ODS-silica, YMC ODS, 15 cm x 6.0 mm i.d., phenyl-bonded silica gel, YMC phenyl, 10 cm x 6.0 mm i.d. eluent, aqueous acetonitrile. Compounds, x, polycyclic aromatic hydrocarbons O, alkylbenzenes O,polychlorobenzenes +, alkanols A, alkanes 1, benzene 2, benzopyrene 3, toluene 4, heptylbenzene 5, hexachlorobenzene 6, hexanol 7, tetra-decanol 8, pentane and 9, octane. 

In line with the above discussion, a very recent paper by Haynes and coworkers again questions the involvement of heme Fe(II) and free ferrous iron in the mode of action of artemisinin and its derivatives . They were able to demonstrate that several highly potent analogues, such as 61 and 62, reacted poorly with FeSOa in aqueous acetonitrile. Compound 61 was also relatively inert to cleavage by heme with 62% recovered after... 

The relatively stable trifluoromethanesulfinic acid azide,14 synthesized from trifluoromethane-sulfinyl chloride and sodium azide, begins to decompose at — 10 C to give the extremely reactive sulfur oxide nitrene 4. The intermediate 4 oligomerizes spontaneously, but in the presence of acetonitrile compound 4 forms the stable dithiatriazine 1,3-dioxide 5. cis- and ri-mw-Isomers of compound 5 can be detected by gas chromatography (ratio 8 10). 

Figure 4 Chromatogram of a mixture of eight steroids. Chromatographic systems (A) ODS-2/0.12moll SDS/6% (v/v) 1-pentanol, and (B) ODS-2/52% (v/v) acetonitrile. Compounds (1) dehydrotestosterone, (2) testosterone, (3) methyltestoster-one, (4) medroxyprogesterone acetate, (5) dydrogesterone, (6) progesterone, (7) testosterone propionate, and (8) nandro-ione.

Previously we showed that the dipole-dipole interaction between the guest molecules has an appropriate magnitude to explain the phase transitions in the hydroquinone clathrate compounds [14,17]. We have now two more substances to compare with the model the phase transition in the hydrogen sulphide compound and the ordered structure of the acetonitrile compound. A Monte Carlo calculation showed that no phase tran-... 

Figure 4 shows the transition temperature of the hydroquinone clathrate compound plotted against the square of the dipole moment of the guest molecule. The data on the hydrogen sulphide, methanol and hydrogen cyanide compounds are those of the heat capacity anomalies. The transition temperature of the acetonitrile compound, if it exists, lies above the room temperature. One finds a good proportionality between the transition temperature and the square of the dipole moment. 

Unactivated aldehydes and ketones do not undergo reduction by NADH analogues readily, however in the presence of HCIO4 and acetonitrile compounds... 

Hydrazine or its salts are known to form amidrazone salts (1) by nucleophilic attack on acetonitrile. Compound 2 (4-amino-3,5-dimethyl-1,2,4-triazole) appears to be formed through six-membered ring... 

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