Natural products originating from acetate pathways

Natural Products Originating from Acetate and Shikimic Acid Pathways... 

Lipids are natural products derived from polyketides which are originated from the acetate pathway. The term lipid has traditionally... 

Of the four major classes of biochemicals (carbohydrates, proteins, nucleic acids and lipids), experiments have shown that the first three classes could have arisen through prebiotic chemistry. Although the biosynthesis of many natural products can be traced back to acetate (e.g. fatty acids, terpenes and polyketide biosynthesis) or amino acids (e.g. alkaloid biosynthesis), there are many whose biosynthetic origins are either obscure or result from a complex combination of pathways (Fig. 2). 

Since the expression of some of the genes originating from plants requires specialized environments or compartments, the host strain E. coli alone is not competent to produce subsequent metabolites after taxadiene in the paclitaxel pathway. The production of taxadine-5 -ol and taxadien-5a-acetate-lO -ol in E. coli and S. cerevisiae consortium brings some inspirations in the heterologous production of natural products (i) we can take full usage of the properties in different species And (ii) spatial segregation the whole pathway into different microbes helps to prevent some internal regulation in the pathway, and pathway modules can be separately optimized. 

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