Acetaminophenols

HPLC method with amperometric detection was applied for detenuination of phenols in sea sediment and some dmg preparation. Peaks of phenol, guaiacol, cresols, hydroquinon and resorcinol were identified on chromatogram of birch tai. The HPLC method with electrochemical detectors was used for detenuination of some drug prepai ation of aminophenol derivate. So p-acetaminophenol (paracetamol) was determined in some drug. 

The ammoximation reaction involves the in situ formation of hydroxylamine via TS-1 catalysed oxidation of NH3 with H2O2. Hence, there are no size restrictions with regard to the ketone substrate, because the reaction of NH2OH with the latter occurs in the bulk solution. For example, TS-1 catalyses the ammoximation of / -hydroxyacetophenone (Le Bars et al., 1996). Beckmann rearrangement of the oxime product (see Fig. 2.18) affords the analgesic paracetamol (4-acetaminophenol). 

Acetaminophen Acetaminophen, p-acetaminophenol (3.2.80), is synthesized by reacting p-aminophenol with acetic anhydride [76,77]. 

SYNS ABENSANIL ACAMOL ACETAGESIC ACETALGIN p-ACETAMIDOPHENOL 4-ACETAMIDOPHENOL ACETAMINOPHEN p-ACETAMINOPHENOL N-ACETYL-p-AMINOPHENOL... 

The reduction of N-alkyl- -nitroanilines to the corresponding cyclo-hexanediamines has been carried out with hydrogen over cobalt-on-alumina and ruthenium catalysts. Sometimes a nuclear-substituted aniline is acetylated before reduction in order to avoid side reactions. Thus, catalytic hydrogenation of p-acetaminophenol and ethyl p-acetaminophenyl-acetate has been successfully accomplished with platinum catalyst at 50-60° in the presence of acetic acid. 

Crystals of 4-acetaminophenol (Tylenol) viewed under polarized light. 

Synonyms APAP 4 -Hydroxyacetanilide p-Hy-droxyacetanilide Acetamide N-(4-hydroxyphenyl) N-Acetyl-p-aminophenol N-Acetyl-p-aminophe-nol p-Acetamidophenol 4-Acetamidophenol 4-Acetaminophenol Paracetamol Tylenol Chemical/Pharmaceutical/Other Class Acetaminophen is a synthetic nonopioid congener of acetanilide in the p-aminophenol class Chemical Eormula C8H9NO2... 

Acetaminophen is also known as paracetamol or p-acetaminophenol, an analgesic... 

The para isomer is a key intermediate in the Hoechst Celanese process for the manufacture of paracetamol (p-acetaminophenol) [2] the ortho isomer can be used for the synthesis of salicylic acid. Other hydroxyarylketones of commercial importance also result from the Fries rearrangement, e. g. 2,4-dihydroxybenzophe-none, an intermediate in the preparation of UV absorbents [3], and diphenol monomers which can be used for the manufacture of advaneed polymers [4], etc. 

Liquid Crystal Polymer, composed from mainly 4-hydroxybenzoic acid or 6-hydroxy-2-naphthoic acid, further, depending on type p-acetaminophenol, terephthalic acid, and biphenol" ... 

Acetamidophenol p-Acetamidophenol. See4-Acetaminophenol 4-Acetamidophenyl salicylate. See Acetaminosalol... 

Acetamine diazo black RD. See Dianisidine Acetamine yellow CG. See Disperse yellow 3 Acetaminophen. See 4-Acetaminophenol 4-Acetaminophenol... 

CAS 103-90-2 EINECS/ELINCS 203-157-5 Synonyms 4-Acetamidophenol p-Acetamidophenol Acetaminophen p-Acetaminophenol N-Acetyl-4-aminophenol APAP 4-Hydroxyacetanilide p-Hydroxyacetanilide 4-Hydroxyphenylacetamide N-(4-Hydroxyphenyl) acetamide Paracetamol... 

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