Acetaminophen yield calculation

Weigh the crystallized acetaminophen and calculate the percentage yield (MW = 151.2). This calculation should be based on the number of moles of the limiting reagent used at the beginning of this procedure. Determine the melting point of the product. 

In addition, taking the ratio of pixels calculated to belong to each component to the total number of pixels yields the following abundance estimates 41% for acetaminophen, 42% for aspirin and 12% for caffeine. 

In addition, taking the ratio of pixels calculated to belong to each component to the total number of pixels yields the following abundance estimates 41% for acetaminophen, 42% for aspirin, and 12% for caffeine. There are other components in the tablet, composing the remaining 16% of the tablet. These excipients were not included in the initial model, so the results for the three API components need to be normalized to their expected contribution to the whole tablet. When normalized to a total contribution of 84%, the abundance estimations are 36% for acetaminophen, 37% for aspirin, and 11% for caffeine. These values compare favorably with the manufacturers label claim of 37% for acetaminophen, 37% for aspirin, and 10% for caffeine. 

Weigh the crystallized acetaminophen (MW = 151.2) and calculate the percentage yield. This calculation should be based on the number of moles of the limiting reagent used at the beginning of this procedure. Determine the melting point of the product. Compare the melting point of the final product with that of the crude acetaminophen. Also compare the colors of the crude, decolorized, and pure acetaminophen. Pure acetaminophen melts at 169.5-171°C. Place your product in a properly labeled vial and submit it to your instructor. 

Repeat this rinsing with two additional 0.5-mL portions of ice-cold water. Dry the crystals for 5-10 minutes by allowing air to be drawn through them while they remain on the Hirsch funnel. Transfer the product to a watch glass or a clay plate and allow the crystals to dry in air. It may take several hours for the crystals to dry completely, hut you may go on to the next step before they are totally dry. Weigh the crude product and set aside a small sample for a melting point determination and a color comparison after the next step. Calculate the percentage yield of crude acetaminophen (MW = 151.2). Record the appearance of the crystals in your notebook. 

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