Acetamide transport

The amide functionality plays an important role in the physical and chemical properties of proteins and peptides, especially in their ability to be involved in the photoinduced electron transfer process. Polyamides and proteins are known to take part in the biological electron transport mechanism for oxidation-reduction and photosynthesis processes. Therefore studies of the photochemistry of proteins or peptides are very important. Irradiation (at 254 nm) of the simplest dipeptide, glycylglycine, in aqueous solution affords carbon dioxide, ammonia and acetamide in relatively high yields and quantum yield (0.44)202 (equation 147). The reaction mechanism is thought to involve an electron transfer process. The isolation of intermediates such as IV-hydroxymethylacetamide and 7V-glycylglycyl-methyl acetamide confirmed the electron-transfer initiated free radical processes203 (equation 148). 

Aprotic solvent enhanced transport (n-Methyl-2-Pyrrolidone, Pyrrolidone, Dimethyl acetamide, Dimethyl formamide, Dimethyl isosorbide)... 

In recent studies, using antidiuretic hormone-treated toad urinary bladder, Levine and Worthington [52] have been able to demonstrate experimentally the presence of co-transport of labeled methylurea and, to a lesser degree, acetamide and urea with unlabeled methylurea. They concluded that the demonstrations of co-transport is consistent with the presence of ADH-sensitive amide-selective channels rather than a mobile carrier. 

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