Acepromazine pharmacokinetics

Phenothiazines (acepromazine, propio-promazine, promazine, trimepra-zine, methotrimeprazine, thioridazine, chlorpromazine) 7.5-64,000 2.2-66.5 1.0-3.7 Acepromazine was determined in horse plasma with good results the method is suitable for pharmacokinetic studies 43... 

Little is known about the pharmacokinetics and biotransformation of acepromazine in food-producing animals. After intramuscular injection of 0.1 mg/ kg bw to horses, the unchanged acepromazine was detectable in plasma 1.5-3 h... 

Artru A A 1990 Hypocapnia and diazepam reverse and midazolam or fentanyl attenuates ketamine induced Increase of cerebral blood volume and/or cerebrospinal fluid pressure. In Domino E F (ed) Status of ketamine in anesthesiology. NPP Books, Ann Arbor, Ml, p. 119 Aurich C, Aurich J E, Klug E 1993 Naloxone affects gastrointestinal functions and behaviour in horses. Deutsche Tierarztiiche Wochenschrift 100 314-315 Ballard S, Shults T, Kownacki A A et al 1982 The pharmacokinetics, pharmacological responses and behavioral effects of acepromazine in the horse. 

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