Viloxazine Acenocoumarol

Interfering acenocoumarol, alminoprofen, amodiaquine, benazepril, benperidol, chloro-quine, cicletanine, cocaine, dipyridamole, do o lamine, droperidol, hydroxychloroquine, ke-toprofen, labetalol, meperidine, mepivacaine, mexiletine, moclobemide, nomifensine, pi-pamperone, pyrimethamine, secobarbital, temazepam, ticlopidine, trazodone, viloxazine, vincristine, vindesine, zolpidem... 

A single report describes three cases where viloxazine possibly increased the anticoagulant effects of acenocoumarol and fluindi-... 

An 82-year-old woman with angina, hypertension and atrial fibrillation, who was taking acenocoumarol, molsidomine and flunitrazepam, had a rise in her INR from 3.3 to 7.9 when she started to take viloxazine (dose not stated) for depression. Five days after stopping the viloxazine her INR had fallen to 2.6. This report also briefly describes 2 other cases where viloxazine possibly caused an increase in the anticoagulant effects of acenocoumarol and fluindione. ... 

Information seems to be limited to this report so that its general importance is uncertain. Be alert for the need to reduce the dosage of acenocoumarol and fluindione if viloxazine is added to established anticoagulant treatment. Take the same precautions with any of the other coumarin or in-danedione anticoagulants, but so far there seems to be no direct evidence that they interact. 

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