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Acebutolol hydrochloride

Acebutolol. Acebutolol hydrochloride is a hydrophilic, cardioselective P-adrenoceptor blocker that has about 1/25 the potency of propranolol in this regard. The dmg has moderate ISA and weak membrane stabilizing activities. It is approved for the treatment of hypertension and ventricular arrhythmias, especially PVCs. Acebutolol should produce minimal depression of heart rate because of its ISA (32). [Pg.119]

Beta-adrenergic blocking agents, selective, intrinsic sympathomimetic activity (ISA) acebutolol hydrochloride... [Pg.602]

Acebutolol hydrochloride Bulk TLC Silica (KOH Ammonium hydroxide- Char GC [2], HPLC [3] Also. [1]... [Pg.143]

Infra-red Spectrum. Principal peaks at wavenumbers 1665,1245, 1525, 1495, 1217, 1285 (acebutolol hydrochloride, KBrdisk). [Pg.309]

Methyl Hydroxybenzoate 133d Hydroxyurea 141-144 Acebutolol Hydrochloride... [Pg.1087]

Abbreviated names for radicals and groups, xiii Abbreviations, xix Abicol,375, 958 Abiocine, 547 Absolute alcohol, 593 Absorbance, 222 Absorbance, specific, 223 Absorption of drugs in the body, 276 Absorptivity, 223 Abyssinian Tea, 437 Accumulation of drugs in the body, 284 Accurbron, 1011 Acebutolol, 309 Acebutolol hydrochloride, 309 Acecainide, 310 (metabolite), 924 Acecainide hydrochloride, 310... [Pg.1173]

ACEBUTOLOL HYDROCHLORIDE (Apo-Acebutolol, Gen-Acebutolol, Gen-AcebutololType S, Monitan, Novo-Acebutolol, Nu-Acebutolol, Rhotral)... [Pg.36]

Fig. 6.2-97 Scanning electron micrographs of single dry crystals of acebutolol hydrochloride and of spherically agglomerated crystals [6.2.3.4]... Fig. 6.2-97 Scanning electron micrographs of single dry crystals of acebutolol hydrochloride and of spherically agglomerated crystals [6.2.3.4]...
The spectrophotometric determination of the following antibiotics has been performed based on the reactivity with iodine ampicillin, penicillin V, amoxycillin, cloxacillin, cefadroxil, ceftezoxime, grise-ofulvin, streptomycin, nicoumalone, and acebutolol hydrochloride. An excess of iodine of known concentration is added to the drug alkaline solution and the unreacted iodine monitored through the decrease in the absorbance of the dye wool fast blue at 540 nm. The determination of pentoxifylline is also based on adding a known excess of standard iodine solution under alkaline conditions and the excess of iodine determined at pH 3.0 with metol-isoniazid (620 nm) or also with wool fast blue (540 nm). [Pg.4519]

El-WaUly A. F. Analysis of nifedipine-acebutolol hydrochloride hinary comhination in tablets using UV-derivative spectroscopy, capillary gas chromatography and high performance liquid chromatography. J. Pharm. Biomed. Anal. 1997,16, 21-30. [Pg.375]

SYNTHESIS AND CHARACTERIZATION OF PH SENSITIVE POLY(VINYL ACETATE-CO-METHACRYLIC ACID) MICROSPHERES FOR CONTROL RELEASE OF ACEBUTOLOL HYDROCHLORIDE... [Pg.101]

Sodium lauryl sulfate, Potassium per sulfate, Vinyl acetate, Methaciylic acid, and N, N -methylene bis acrylamide—all chemicals purchased by S. D. Fine chemicals, Mumbai, India. Acebutolol hydrochloride was given as gift sample by Waksman Saleman Pharmaceuticals, Anantapur, India. [Pg.103]

The development of copolymeric microspheres of poly (Virtyl Acetate-Co-Mehtacrylic acid) for in vitro release of Acebutolol hydrochloride is an antihypertensive dmg. These copolymeric microspheres were crosslinked with A,A/ -methy-lene bis acrylamide have been prepared by the flee radical emulsion polymerization nsing varying amoimts of dnyl Acetate (VAc), Mehtacrylic acid (MAc) and N,N-methylene bis acrylamide (NNMBA), which, for controlled release of Acebutolol hydrochloride were loaded into these microspheres during in situ polymerization. [Pg.104]

FIGURE 7.1 DSC thermograms of plain Acebutolol hydrochloride (A), plain Poly (VAc-co-MAA) Microspheres (B), drug-loaded Poly (VAc-co- MAA) microspheres(C). [Pg.107]

X-RD analyses provide a clue about ciystallinity of the drug in the cross-linked microspheres. X-RD patterns recorded for poly (VAc-co-MAA) microspheres are shown in Figure 7.2. (A) Plain dmg microspheres, (B) dmg-loaded microspheres, and (C) plain microspheres. In the Figure 7.2 (A) the Acebutolol hydrochloride peaks are observed at 20 of 16,19,21 and 29, suggesting its ciystalline nature. But, these peaks are not found in dmg-loaded microspheres. Figure 7.2 (B) indicating that dmg is dispersed at a molecular level in the polymer matrix. [Pg.108]

FIGURE 7.3 Scanning electron micrograph of Acebutolol hydrochloride-loaded poly (VAc-co-MAc) microspheres. [Pg.109]

TABLE 7.1 Results of percentage of encapsulation efficiency and mean particle diameter of Poly (VAc-co-MAc) microspheres with different amounts of cross-linking agent, monomer concentration and Acebutolol hydrochloride... [Pg.111]

Sample code % (VAc) % MAC % NNM- BA Acebutolol hydrochloride % Encapsulation efficiency SD Mean particle diameter (mm) SD... [Pg.111]

FIGURE 7.5 Percentage of Cumulative release of Acebutolol hydrochloride through Poly (VAc-co-MAc) microspheres containing different amount of cross-linking agent ( ) 3%, (A) 2% and (") 1% at 37 °C. [Pg.113]

See other pages where Acebutolol hydrochloride is mentioned: [Pg.3]    [Pg.116]    [Pg.503]    [Pg.508]    [Pg.6]    [Pg.601]    [Pg.3]    [Pg.309]    [Pg.1080]    [Pg.1149]    [Pg.3]    [Pg.1383]    [Pg.102]    [Pg.103]    [Pg.106]    [Pg.109]    [Pg.110]    [Pg.112]    [Pg.113]   
See also in sourсe #XX -- [ Pg.7 ]

See also in sourсe #XX -- [ Pg.36 ]



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