Accidental self-injection

In humans, the product produces hyperpnoea on administration and apnoea following overdose. It also produces marked depression in cardiopulmonary function in humans and in other animals.There are no reports of adverse reactions in humans following accidental self-injection or through any other routes of exposure and Salfan has largely been replaced by other injectable anaesthetics and notably by propofol (Chapter 5). 

N. M. Shah, G. K. Mangat, C. Balakrishnan, V. I. Buch and V. R. Joshi, Accidental self-injection with Freund s complete adjuvant, J. Assoc. Physic. India, 2001, 49, 366 368. 

Reports of macrolides causing adverse reactions in humans relate primarily to medicated stockfeed and parenteral formulations for injection. Farmworkers exposed to stockfeed medicated with spiramycin and tylosin have developed dermatitis and bronchial asthma. In addition, accidental needlesticks with needles contaminated with tilmicosin have caused minor local reactions, whereas accidental self-administration of injectable formulations of tilmicosin has resulted in serious cardiac effects and death. 

Singer AJ. Accidental digital self-injection of epinephrine debunking the myth. Ann Emerg Med 2010 56(3) 275-7. 

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