Respiration acaricides

Mitochondrial respiration, insecticides and acaricides acting on, 14 348-349 Mitosis, in plants, 13 302 Mitotic entry inhibitors, 13 302-303 Mitotic sequence, disruption of,... 

Many of the new acaricides appear to affect mitochondrial respiration, and mite growth and development (for an overview, see Dekeyser, 2005). 

In the mode of action of benzimidazoles, the carrier of the fungicidal action is the benzimidazole ring, common to all of the derivatives. The substituents, however, particularly in position 2, strongly influence this action. Therefore, in addition to the common mode of action, different side-effects can be observed for certain active substances. Thus, a respiration-inhibiting action was observed for thiabendazole (Allen and Gottlieb, 1970) and an acaricidal action for benomyl, thiophanates and MBC (Nakashima and Croft, 1974), while 2-trifluoromethyl benzimidazole are primarily acaricides. 

In the patent literature, many claims and some data can be found about insecticidal and acaricidal activities of strobilurins. Attempts to optimize insecticidal performance did not lead to a commercial product. It seems that, with strobilurins, sufficient insecticidal activity can only be obtained if the compound has very high lipophilicity and very high metabolic stability. This combination of properties gave numerous compounds with excellent insecticidal activity but also with unacceptably high acute mammalian toxicity, so that candidates were abandoned rather early in the research phase. It seems impossible to separate the tight connection between insecticidal and mammalian toxicity in this particular case. Similar problems have been reported for respiration inhibitors of Complex I [82a]. 

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