Acaricides Acting as Neurotoxins

Milbemectin is a GABA agonist. Therefore, for those acaricides that also possess high insecticidal activity, they share the same modes of action as found in insects. Table 7.2 summarizes the biochemical sites of action of insecticides and acaricides. [Pg.138]

Target site Insecticide/insecticide class Mode of action [Pg.139]

Voltage-gated Na channels The DDT group, pyrethroids, Sabadilla Indoxacarb Delayed Na inactivation (Na channel modulators) Na channel blocker [Pg.139]

GABA-gated chloride channels Cyclodienes, lindane, phenylpyrazoles, Avermectins, emamectin benzoate, milbemectin Antagonism Chloride channel activators [Pg.139]

Nicotinic acetylcholine receptor Nicotine, neonicotinoids, spinosyns Agonism [Pg.139]

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