Acanthifolicin from Pandaros acanthifolium

Additional pharmacological studies on the cytotoxic compound acanthifolicin (95), the 9,10-episulfide derivative of okadaic acid obtained from sponge Pandaros acanthifolium [103], showed it to be an inhibitor of phosphatases 1 and 2a (PP1-1 and PP-2a) with similar potencies to okadaic acid [104]. 

Schmitz, F.I, Prasad, R.S., Gopichand, Y, Hossain, M.B., van der Helm, D., and Schmidt, P. 1981. Acanthifolicin, a new episulfide-containing polyether carboxylic acid from extracts of the marine sponge Pandaros acanthifolium. J Am Chem Soc 103, 2467-2469. 

Schmitz, F.J., R.S. Prasad, Y. Gopichand, M.B. FIossain, D. van der Helm, and P. Schmidt Acanthifolicin, a New Episulfide-Containing Polyether Carboxylic Acid from Extracts of the Marine Sponge Pandaros acanthifolium. J. Am. Chem. Soc. 103, 2467 (1981). 

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