Abundance behaviour, dynamics

Metabolic rhythms underlie population dynamics, behaviour and distribution, despite their complicated nature. As a corollary, the influences of abundance and complex behaviour patterns on metabolism are equally important. The relationship between metabolism and population dynamics appears to be simple. Nikolsky (1974) regarded recruitment, adult stock, total mortality and food supply as interdependent parts of the whole. 

Variable-temperatxure H NMR studies on human bile show that considerable dynamic structural information is available, particularly at very high fields, e.g. 600 MHz. Hie micellar cholesteryl esters that are abundant in bile appear to show liquid crystal behaviour, and it is possible to use NMR measurements to map the phase diagram for the complex biliary matrix. 

Through-bond and through-space solid-state NMR correlation experiments including CP-INADEQUATE at natural isotope abundance have been applied by Brus and Jegorov to establish the structure and dynamic behaviour of simvastatin (C25H38O5), an active metabolite which inhibits 3-hydroxy-3-methyl-glutaryl coenzyme A, (HMG-CoA) reductase, the enzyme that is necessary in an early step of the cholesterol synthesis. 2D INADEQUATE spectroscopy has been applied by Meier et to establish the structures of a series of fullerene derivatives. 

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