Absorption of griseofulvin

M Kraml, J Dubuc, D Beall. Gastrointestinal absorption of griseofulvin. I. Effect of particle size, addition of surfactants and corn oil on the level of griseofulvin in the serum of rats. Can J Biochem Physiol 40 1449-1451, 1962. 

M Kraml, J Dubuc, R Gaudry. Gastrointestinal absorption of griseofulvin II. Influence of particle size in man. Antibiot Chemother 12 239-242, 1962. 

Jamali F, Axelson JE. Influence of metoclopramide and propantheline on GI absorption of griseofulvin in rats. J Pharm Sci 1977 66 1540-1543. 

Carrigan, P.J., and T.R. Bates. 1973. Biopharmaceutics of drugs administered in lipid-containing dosage forms. I. GI absorption of griseofulvin from an oil-in-water emulsion in the rat. J Pharm Sci 62 1476. 

Chiou, W.L. Riegelman, S. Oral absorption of griseofulvin in dogs increased absorption via solid dispersion in polyethylene Glycol 6000. J. Pharm. Sci. 1970, 59, 937-942. 

The absorption of griseofulvin with normal particle size in humans is minimal and unpredictable. However, the absorption can be increased by the costly process of size reduction to microsize or ultramicrosize [56]. 

Pharmacokinetics Oral absorption of griseofulvin depends on the physical state of the drug—ultramicrosize formulations, which have finer crystals or particles, are more effectively absorbed—and is aided by high-fat foods. The drug is distributed to the stratum corneum, where it binds to keratin. Biliary excretion is responsible for its elimination. 

Rosenkrantz, B., and Townley, E. Parameters Affecting Absorption of Griseofulvin in a Human Subject Using Urinary Metabolite Excretion Data J. Pharm. Sci. 59(5) 595-600 (1970) ... 

Chiou and Riegelman reviewed the pharmaceutical applications of solid dispersion systems. These authors found complete and rapid absorption of griseofulvin dispersed in polyethylene glycol 6000 for both capsule and tablet dosage forms, in contrast to irregular and incomplete absorption from commercially available micronized drug. Munzel reviewed various formulation variables which can influence drug action. Kakemi and co-workers studied the effects of buffer components, osmotic... 

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