Absorption cinnamyl anthranilate, effect

The effect of different receptor fluids on cinnamyl anthranilate absorption w ls determined by comparing values obtained at the end of 5 days (Table I). Only 12.7/1 of the compound absorbed in vivo in the 5-day period was obtained in a corresponding in vitro experiment using normal saline receptor fluid and split-thickness rat skin. A 1.5 solution of the... 

Rabbit serum and bovine serum albumin had no effect on the integrity of the barrier, but they were also less effective in increasing cinnamyl anthranilate absorption than oleth 20. A methanol-water solution and 6> octoxynol 9 (Triton X-100, Rohm and Haas Co., Philadelphia, PA) were equal to or superior to (>% oleth 20, but significant damage to the skin was Indicated by the increased cortisone permeation. A 6% solution of poloxamer 188 in the receptor resulted in slight enhancement of both cinnamyl anthranilate and cortisone permeation. 

Table I. Effect of Diffusion Cell Conditions on the Absorption of Cinnamyl Anthranilate (I) (Cortisone Control) ...

Figure 2. Effect of cell type and receptor fluid on absorption of cinnamyl anthranilate. Cinnamyl anthranilate was applied to the rat skin membrane in a petrolatum vehicle. Receptor fluid was either normal saline solution or 6 oleth 20 in water. Absorption was expressed as the cumulative amount of compound penetrating the skin. Flow-through oell Q= normal saline,0 = oleth 20 static cell / = normal saline,oleth 20.

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