Abasic site Revlp bypass

The apparent conflict between the in vivo and in vitro results may perhaps be explained by Revlp existing within a complex in the cell, in which dCMP insertion is inhibited at template sites other than those with abasic residues and, perhaps, some other lesions. Finally, the deoxycytidyl transferase activity, even if not essential for the bypass of abasic sites, nevertheless doubles the efficiency of rephcation past this lesion in yeast (Otsuka et al., 2002b see also Section III), perhaps explaining why the activity has been maintained throughout evolution. 

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