A Structure and Function Mimic

The final synthesis of target molecule 12.13 was never completed, but it seems that a systematic study of the reactivity of the compound with a range of acylating agents would produce a potent enzyme mimic. Clearly, however, the studies on 12.14 and 12.17 and a range of related compounds 

Fenton, D. E. MetaUobiosites and their synthetic analogues—a belief in synergism , Chem. Soc. Rev., 1999, 28, 159-168. 

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Pasqualini R, Koivunen E, Ruoslahti E, A peptide isolated from phage display libraries is a structural and functional mimic of an RGD-binding site on integrins, J. Cell. Biol., 130 1189-1196, 1995. 

Canaguier S, Field M, Oudart Y, Pecaut J, Fontecave M, Artero V (2010) A structural and functional mimic of the active site of NiFe hydrogenases. Chem Commun 46(32) 5876-5878. doi 10.1039/c001675f... 

Omer BP, Ernst JT, Hamilton AD. Toward proteomimetics terphenyl derivatives as structural and functional mimics of extended regions of an a-helix. J Am Chem Soc 2001 123 ... 

Clearly, while porphyrin complexes are obvious candidates for modelling these kinds of biomimetic oxidations, a range of non-heme iron complexes based on macrocyclic and podand ligand have also proved to be successful structural and functional mimics.19 To take one example, Figure 12.13 shows the X-ray structure of the iron (IV) tetramethylcyclam (tmc) oxo complex [Felv(tmc)(0)(MeCN)]2+... 

Butler, A. Baldwin, A.H. (1997)Vanadium Bromoperoxidase and Functional Mimics. In Structure and Bmiding Metal Sites in Proteins and Models, Lewis Acids, and Vanadium, Sadler, P., Hill, H.A.O., Thompson, A., eds. Springs-Vwlag, New York, Volume 89, pp. 109-131. 

Modern nanotechnology and nanofabrication processes are advancing towards manipulation of structure and functions on the molecular scale [19-23]. Many innovations and strategic areas of research which have appeared during the last 5-10 years corroborate the famous opinion of R. Feynman there is a plenty of space on the bottom [471]. Some prominent examples include self-assembly of small molecules and their ordering at interfaces [8,220,472,473 ], three-dimensional macromolecules with a defined shape, interior and surface structure [34-38], and templating of biomolecules [39-41,474]. Most of these concepts follow a biomimetic approach, where synthetic structures mimic organisation princi-... 

There are two basic kinds of chemical models structural and functional. Functional models are harder to design and may not physically resemble the system they are designed to mimic (e.g. hydraphiles) but do make use of the same concepts. Was can also distinguish confirmatory and speculative models depending on whether the model is based on a known biological structure or not. 

Yannas s invention mimics the structure and function of the upper two layers of natural skin. It consists of an upper layer about 0.023 mm thick made of an elastic silicone material that, like the human epidermis, acts as a harrier to the loss of moisture from the body. Silicones are siloxane polymers to which are bonded various organic radicals (groups of atoms that contain carbon). The chemical structures of siloxane and a typical silicone polymer are shown on page 50. 

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