A-oxidation products

The presence or absence of the dioxolane protecting group in dienes dictates whether they participate in normal or inverse-electron-demand Diels-Alder reactions.257 The intramolecular inverse-electron-demand Diels-Alder cycloaddition of 1,2,4-triazines tethered with imidazoles produce tetrahydro-l,5-naphthyridines following the loss of N2 and CH3CN.258 The inverse-electron-demand Diels-Alder reaction of 4,6-dinitrobenzofuroxan (137) with ethyl vinyl ether yields two diastereoisomeric dihydrooxazine /V-oxide adducts (138) and (139) together with a bis(dihydrooxazine A -oxide) product (140) in die presence of excess ethyl vinyl ether (Scheme 52).259 The inverse-electron-demand Diels-Alder reaction of 2,4,6-tris(ethoxycarbonyl)-l,3,5-triazine with 5-aminopyrazoles provides a one-step synthesis of pyrazolo[3,4-djpyrimidines.260 The intermolecular inverse-electron-demand Diels-Alder reactions of trialkyl l,2,4-triazine-4,5,6-tricarboxylates with protected 2-aminoimidazole produced li/-imidazo[4,5-c]pyridines and die rearranged 3//-pyrido[3,2-[Pg.460]

A-oxidation product. The extent of O-demethylation appears to be genetically determined being decreased in poor metabolisers. 

Li12[Mnn2ZnW (ZnW90 34)2] Alkanes, alkylarenes Ketones, a-oxidation products Ozone h2o Likely metal-ozonide intermediate 461... 

This tissue is known to contain a high level of cytochromes P-450 activity. Clearly it is similar to the lung in exposure. An example is the industrial chemical trifluoromethylpyridine which specifically damages the olfactory epithelium in animals exposed to it in the inspired air. The compound is metabolized by A-oxidation and the A-oxide product (or a nitroxide radical) is believed to be responsible for the toxicity (figure 4,20). The activity for this metabolic pathway is particularly high in the olfactory epithelium. 

Sanford and coworkers have reported the use of Oxone in combination with palladium acetate for the oxime-ether directed C-H oxygenation of arenes (eq 111). A range of substituted arenes are tolerated under the reaction conditions and the use of Oxone rather than periodate-based oxidants afforded A -oxidized products in some cases. 

When coke (a form of carbon) reacts with iron ore in a blast furnace, the coke is the (a) oxidation product, (b) reducing agent, (c) oxidizing agent. 

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