A Novel Triple Helix Consisting of One Polynucleotide and Two Polysaccharide Chains

Kazuo Sakurai, Kazuya Koumoto and Seiji Shinkai 

Recently, we found that when certain single-stranded polynucleotides such as poly(5 -cytidine monophosphate), denoted by poly(C), coexists in the renature process of P-(1 3)-glucans mentioned above, the polynucleotide and s-SPG form a macromolecular complex.Our subsequent studies show that this complexa-tion is a characteristic nature commonly observed for all P-(1 3)-glucans. As far as we know, this is the first study showing that a neutral polysaccharide can combine with polynucleotides. If s-SPG can enter a cancer cell and combine with 

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A Novel Triple Helix Consisting of One Polynucleotide and Two Polysaccharide Chains... 

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