A new model for biology

It is possible that quite different molecular architectures may occur in membranes from different sources. Current research may result in a much more dramatic revision or complete rejection of the bilayer model for some membranes, especially in such systems as mitochondria (30) and chloroplasts (2). However, it is also possible that structural differences are only variations on the basic theme of the bilayer, from myelin at one extreme to mitochondria or chloroplasts on the other. One must not readily reject the fundamentals of the Danielli concept, especially in view of the present inadequate knowledge of the properties of phospholipids in water. Clearly the molecular architecture of membranes is speculative, but most aspects of the problem are amenable to direct experimental test by the new physical techniques. A consistent model for biological membranes will emerge quickly. 

Kubinyi, H. (1977). Quantitative Structure-Activity Relationships. 7. The Bilinear Model, a New Model for Nonlinear Dependence of Biological Activity on Hydrophobic Character. J.Med. Chem., 20,625-629. 

Kubinyi, H. (1977) Quantitative structure-activity relationships. 7. The bilinear model, a new model for nonlinear dependence of biological activity on hydrophobic character. J. Med. Chem.,... 

Patel, N.M., Constantinidou, D., Ali, S. and Nakshatri, H. (2001) Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor a a new model for anti-estrogen resistance. The Journal of Biological Chemistry, 276, 9817-9824. 

Gennis RB, Stewart V (1996) Respiration. In FC N (ed) Escherichia coli and Salmonella cellular and molecular biology, vol 1. ASM Press, Washington, DC, pp 217-261 Gonzalez R, Murarka A, Dharmadi Y, Yazdani SS (2008) A new model for the anaerobic fermentation of glycerol in enteric bacteria trunk and auxiliary pathways in Escherichia coli. Metab Eng 10 234-245... 

Corbett, M. D. and B. R. Corbett. 1990. Biochemical studies on the putative nitroso metabolite of chloramphenicol a new model for the cause of aplastic anemia, p. 245-255. In P.C. Howard, S.S. Hecht and F.A. Beland (ed.), Nitroarenes occurrence, metabolism and biological impact. Plenum Press, New York. 

To help address these issues, we define a new component for use in conceptual models the units of analysis. These are the lowest levels of biological, spatial, and temporal scale used in the quantitative part of the risk assessment (e.g., individual iterations in a simulation model). They also define the biological, spatial, and temporal units of the measures that will be needed as inputs to the assessment model. 

Perrin, D. D., Agarwal, R. P. Multielement-multigand equilibria a model for biological systems, in Metal Ions in Biological Systems, (ed.) Sigel, H., Vol. 2,. p. 167, New York— Basel Marcel Dekker, Inc. 1973... 

Use of multiple regression techniques in the study of functional properties of food proteins is not new I76) Most food scientists have some familiarity with basic statistical concepts and some access to competent statistical advice. At least one good basic text on statistical modelling for biological scientists exists (7 ). A number of more advanced texts covering use of regression in modelling are available (, ). ... 

One of the last attempt to propose a common pharmacophoric model was made in 2001 by some of us, building a new pseudoreceptor for taxanes and epothilones [114] to account for the amount of new structural and biological information available since the first attempt of the minireceptor work [82], A set of 12 taxanes and epothilones was used as training set on which the model was built. The small... 

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