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A-ketol

BREDERECK Imidazole synthesis Synthesis o( imidazoles Irom (ormamide (acetamide) and a-diketones, a-ketols, a-aminoketones, a-oziminoketones... [Pg.48]

LIEBIG BenzyBc Aad Rearrangement Benzylic a<5ds by rearrangement of diketones (also a-ketol rearrangement)... [Pg.235]

WEIDENHAQEN Invdazotosynthesis Imidazole synthesis from a-ketols, formaldehyde and ammonia. [Pg.406]

As first demonstrated by Stork,the metal enolate formed by metal-ammoni reduction of a conjugated enone or a ketol acetate can be alkylated in liquic ammonia. The reductive alkylation reaction is synthetically useful since ii permits alkylation of a ketone at the a-position other than the one at whicf thermodynamically controlled enolate salt formation occurs. Direct methyl-ation of 5a-androstan-17-ol-3-one occurs at C-2 whereas reductive methyl-... [Pg.46]

Nickel peroxide is a solid, insoluble oxidant prepared by reaction of nickel (II) salts with hypochlorite or ozone in aqueous alkaline solution. This reagent when used in nonpolar medium is similar to, but more reactive than, activated manganese dioxide in selectively oxidizing allylic or acetylenic alcohols. It also reacts rapidly with amines, phenols, hydrazones and sulfides so that selective oxidation of allylic alcohols in the presence of these functionalities may not be possible. In basic media the oxidizing power of nickel peroxide is increased and saturated primary alcohols can be oxidized directly to carboxylic acids. In the presence of ammonia at —20°, primary allylic alcohols give amides while at elevated temperatures nitriles are formed. At elevated temperatures efficient cleavage of a-glycols, a-ketols... [Pg.248]

Alcoholic potassium hydroxide or sodium hydroxide are normally used to convert the halohydrins to oxiranes. Other bases have also been employed to effect ring closure in the presence of labile functional groups such as a-ketols, e.g., potassium acetate in ethanol, potassium acetate in acetone or potassium carbonate in methanol.However, weaker bases can lead to solvolytic side reactions. Ring closure under neutral conditions employing potassiunT fluoride in dimethyl sulfoxide, dimethylformamide or A-methyl-pyrrolidone has been reported in the patent literature. [Pg.17]

FIGURE 23.34 The tnechanistn dependent transketolase reaction. Ii the group transferred in the transk( don might best be described as an t whereas the transferred group in th dolase reaction is actually a ketol. D irony, these names persist for histor... [Pg.767]

D. Haring, T. Konig, B. Withopf, M. Herderich and P. Schi eier, Enantiodifferentiation of a-ketols in sherry by one- and two-dimensional HRGC tecliniques , J. High Resolut. Chromatogr. 20 351-354 (1997). [Pg.74]

If the reaction is carried out with ketone labeled in the C=0 group with the first pathway predicts that the product will contain all the " C in the C=0 carbon, while in the second pathway the label will be in the a carbon (demonstrating migration of oxygen). The results of such experiments have shown that in some cases only the C=0 carbon was labeled, in other cases only the a carbon, while in still others both carbons bore the label, indicating that in these cases both pathways were in operation. With a-hydroxy aldehydes and ketones, the process may stop after only one migration (this is called the a-ketol rearrangement). [Pg.1401]

In aqueous solution the rate law for oxidation of simple a-ketols, such as acetoin and benzoin and various aldoses and ketoses o. sog-sioj markedly different from that of Wiberg and Nigh (vide supra), viz. [Pg.431]

Asymmetric synthesis of the rocaglamides was accomplished by employing [3+2] photo-cycloaddition mediated by functionalized TADDOL based chiral Brpnsted acids. The synthesis consisted of a [3+2] dipolar cycloaddition, a base-mediated a-ketol rearrangement and a hydroxyl-directed reaction <06JA7754>. Asymmetric synthesis of 1,2-dihydrobenzo /j]furans was achieved by adamantylglycine derived dirhodium tetracarboxylate catalyzed C-H insertion <06OL3437>. [Pg.195]

Synthetic routes to a-ketol through the reactions of an unmasked acyl anion with carbonyl compounds are not numerous. The first practical application of an acylzirconocene chloride as an unmasked acyl anion donor was reported in the reaction with aldehydes in 1998 (Scheme 5.12 and Table 5.1) [19]. [Pg.155]

Phosphorylation of ketonesKetones bearing an adjacent methylene group react directly with 1 to form a-ketol phosphates in 60-80% yield. The reagent also effects cyclization of 4-pentenoic acid to a phosphorylated lactone. [Pg.179]


See other pages where A-ketol is mentioned: [Pg.391]    [Pg.509]    [Pg.897]    [Pg.33]    [Pg.43]    [Pg.46]    [Pg.240]    [Pg.242]    [Pg.249]    [Pg.251]    [Pg.587]    [Pg.874]    [Pg.279]    [Pg.856]    [Pg.857]    [Pg.430]    [Pg.431]    [Pg.139]    [Pg.141]    [Pg.144]    [Pg.146]    [Pg.148]    [Pg.159]    [Pg.175]    [Pg.891]    [Pg.155]    [Pg.155]    [Pg.156]    [Pg.515]    [Pg.108]    [Pg.152]   
See also in sourсe #XX -- [ Pg.1401 ]

See also in sourсe #XX -- [ Pg.155 ]

See also in sourсe #XX -- [ Pg.155 ]

See also in sourсe #XX -- [ Pg.515 ]




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A-Ketol acetates

A-Ketol acetates iron carbonyls

A-Ketol acetates metals

A-Ketol ester

A-Ketol rearrangement

A-Ketol rearrangement comparison with

A-Ketols

A-Ketols

A-Ketols metal ions

A-Ketols metals

A-Ketols reductive cleavage

A-Ketols via samarium acyl anions

A4-3-Ketosteroid-a-ketols

A5-3-Ketosteroid-a-ketols

Hydroxy-ketones (a-ketols, acyloins)

Ketol

Ketols

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