A-keto acid-dependent dioxygenases

Whiting AK, Que L, Saari RE, Hausinger RP, Fredrick MA, McCracken J. Metal coordination environment of a Cufll)-substituted a-keto acid-dependent dioxygenase that degrades the herbicide 2,4-D. J. Am. Chem. Soc. 1997 119 3413-3414. 

Diebold AR, Brown-Marshall CD et al (2011) Activation of a-Keto acid-dependent dioxygenases application of an FeNO V Fe02 methodology for characterizing the initial steps of O2 activation. J Am Chem Soc 133 18148-18160... 

Other non-heme enzymes that use dioxygen are 4-methoxy-benzoate O-demethylase, extradiol catechol dioxygenases, the oxidoreductase isopenicillin N synthase, and a-keto acid-dependent enzymes (28). Moreover, the BH4-dependent glyceryl-ether monooxygenase (GEM) also appears to be dependent on nonheme iron for catalysis (see also Section I.E). 

Hegg, E.L., Ho, R.YN., and Que, L. Jr. (1999) Oxygen activation and arene hydroxylation by functional mimics of a-keto acid-dependent iron(II) dioxygenases, /. Am, Chem. Soc. 121, 1972-1973 Heinen, U., Berthold, T., Kothe, G., Stavitski, E., Galili, T., Levanon, H., Wiederrecht, G., and Wasielewski, M.R. (2002) High time resolution Q-band EPR study of sequential electron transfer in a triad oriented in a liquid crystal, J. Phys. Chem. A 106, 1933-1937... 

Figure 10 Several reactions catalyzed by a-keto acid-dependent iron enzymes, (a) prolyl 4-hydroxylase, (b) deacetoxycephalosporin C synthase (DAOCS), (c) 4-hydroxyphenylpyruvate (HPP) dioxygenase and (d) clavaminate synthase 2 (CAS)...

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