Glyceryl-ether monooxygenase

Other non-heme enzymes that use dioxygen are 4-methoxy-benzoate O-demethylase, extradiol catechol dioxygenases, the oxidoreductase isopenicillin N synthase, and a-keto acid-dependent enzymes (28). Moreover, the BH4-dependent glyceryl-ether monooxygenase (GEM) also appears to be dependent on nonheme iron for catalysis (see also Section I.E). 

The important metaboUsm of the neurotransmitters norepinephrine, epinephrine, dopa, and serotonin involves pterin-dependent monooxygenases. The direct biocatalytic hydroxylation of the aromatic amino acids phenylalanine, tyrosine, and tryptophane requires tetrahydrobiopterin and Fe as the cofactors [60]. The cleavage of unsaturated glyceryl ethers by glyceryl ether monooxygenase also requires tetrahydrobioterin as the cofactor [61]. 

G. (2007) Widespread occurrence of glyceryl ether monooxygenase activity in rat tissues detected by a novel assay. Journal of Lipid Research, 48,1422-1427. 

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