A-DNA conformation

Figure 11. An externally bound BPDE l(+)-N2(G) adduct, (upper) The pyrene is placed in the major groove after an anti - syn rotation about the glycosidic bond of G by 200° in an otherwise B-DNA conformation. (lower) The pyrene moiety is placed in the minor groove in a DNA conformation with a -70° kink, a(BPDE) = 15° and y(DNA = 35°.

Mei and Barton [66, 67] have used photo-sensitised damage to DNA by /1-Ru(TMP)3 (induced by 02 formation) as a means of probing A-DNA conformations, and they have compared the damage so caused on a linear... 

Mei H-Y, Barton JK.Tris(tetramethylphenanthroline)rathenium(II) a chiral probe that cleaves A-DNA conformations. Proc Natl Acad Sci USA 1988 85 1339-43. 

Two simulations stand out (AT and GC) in Table 3, because the resulting structures are the farthest from A-DNA the same behavior is apparent for E4 at a shorter simulation time. This is actually expected, as alternating purine-pyrimidine sequences are supposed to adopt wrinkled-DNA conformations [103]. The time evolution of the RMSD for AT and GC is shown in Figure 5. These plots illustrate two important points one is that there are long-lived oscillations in the structure (see also [95]). Had the GC simulation stopped after 1 ns, the conclusion would have been that all the sequences are equally likely to be in an A-DNA conformation. The other point is that the distance from A- and... 

The RNA molecules may also occur as complete double helices containing two antiparallel RNA strands, similar to a DNA double helix in the A-DNA conformation. In many RNA molecules, however, double-stranded structures... 

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