A-Aminoketones derivs

Treatment of a-hydroxy-ketones or -aldehydes with ammonium acetate (65BSF3476, 68BSF4970) results in the formation of dihydropyrazines, presumably by direct amination of the hydroxyketone followed by self-condensation (79AJC1281). Low yields of pyrazines have been noted in the electrolysis of ketones in admixture with KI and ammonia, and again it appears probable that the a-aminoketone derived by way of the a-iodoketone is the intermediate (69CI(L)237>. 

A modification of the Feist-Benary furan synthesis (pi34). Reaction between a-aminoketones, derived fron a-haloketones and ammonia, and P-ketoesters assembles pyrroles. 

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See also in sourсe #XX -- [ , ]

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