A2-receptor adrenergic agonists

The clinical effects of a2-adrenergic receptor agonists may also derive from the action of postsynaptic tt2A adrenoceptors, which modulate the excitability of target neurons in select noradrenergic terminal fields in... 

Boyd RE. a2-Adrenergic receptor agonists as analgesics. Curr Top Med Chem 2001 1 193-197. 

Working memory enhancement of a2-adrenergic receptor agonist in T-maze 4... 

Clonidine and other imidazoline compounds have also been shown to reduce muscle spasms by their central nervous system activity. Tizanidine is perhaps the most thoroughly studied clonidine analog. It is an agonist at a2-adrenergic receptors, but reduces spasticity at doses that result in significantly less hypotension than clonidine. 

G and a41 Gj have also been purified from rat [77] and porcine [78] brain and shown to be distinct from each other. Both bovine and rat brain G or Gj were shown in reconstitution studies to interact with muscarinic receptors [79-81], by increasing the binding affinity for muscarinic agonists [80,81]. Platelet a2-adrenergic receptors [82] stimulate the GTPase activity of the bovine G and Gj proteins in... 

Richman JG, Brady AE, Wang Q, Hensel JL, Colbran RJ, Limbird LE. Agonist-regulated interaction between a2-adrenergic receptors and spinophilin. J Biol Chem 2001 276 15,003-15,008. 

Eason MG, Liggett S B. Functional a2-adrenergic receptor-Gs coupling undergoes agonist-promoted desensitization in a subtype-selective manner. Biochem Biophys Res Commun 1993 193 318-323. 

Schramm NL, Limbird LE. Stimulation of mitogen-activated protein kinase by G protein-coupled a2-adrenergic receptors does not require agonist-elicited endocy-tosis. J Biol Chem 1999 274 24,935-24,940. 

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