7V-Nitrosodimethylamine

Toxicology. 7V-nitrosodimethylamine (DMN) is a liver toxin and is carcinogenic in many species of test animals. 

A new route to triazolo[4,5-with sodium nitrite in acetic acid surprisingly gives oxazolo[5,4-[Pg.182]

We will discuss the carcinogenic properties of nitrosoamines in spite of the fact that it seems to be a problem particularly related to N-nitroso derivatives of secondary amines. In 1956, Magee and Barnes found that rats fed with N-nitrosodimethylamine developed hepatic tumors. Nitrosoamines cause alkylation of DNA, as suggested first by Druckrey et al. (1967) and Druckrey (1973). They postulated the pathway shown in (4-10), originally for 7V-nitrosodimethylamine, but likely to be valid for all dialkyl- and cycloalkylamines with at least one H-atom bonded to one of the C(a)-atoms. The nitrosoamine is metabolized by a cytochrome P450-dependent, so-called mixed-function oxidase. This enzyme catalyzes the hydroxylation of the C(a)-atom... 

Dimethyl monosulfate, see Dimethyl sulfate Dimethylnitromethane, see 2-Nitropropane Dimethylnitrosamine, see TV-Nitrosodimethylamine TV-Dimethylnitrosamine, see TV-Nitrosodimethylamine 7V,7V-Dimethylnitrosamine, see TV-Nitrosodimethylamine Dimethylnitrosomine, see TV-Nitrosodimethylamine 2-(2,2-Dimethyl-l-oxopropyl)-l//-indene-l,3(2Efl -dione, see Pindone... 

TV-Nitrosodimethylamine, Thiram 3-(4-(7V-(7V, 7V -Dimethylaminocarbonyl)aniline)phenyl) -l.l -dimethylurea. see Monuron... 

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